Getting tested for BRCA genetic mutation saves lives: U of T expert
We all remember when the actress Angelina Jolie announced she had a double mastectomy, a preventative measure after learning she had the BRCA-1 genetic mutation (she later had her ovaries removed as well). Jolie got herself tested after her mother died of ovarian cancer.
Taking preventative measures could very well have saved Jolie鈥檚 life, says Dr. Mohammad R. Akbari, an assistant professor at 重口味SM鈥檚 Dalla Lana School of Public Health and the Institute of Medical Sciences in U of T鈥檚 Faculty of Medicine.
Anyone with a family member who has been diagnosed with four major cancers 鈥 breast, ovarian, prostate or pancreatic 鈥 should consider getting a simple saliva test to determine if you have the genetic mutations BRCA-1 or BRCA-2, writes Akbari in this week鈥檚 edition of , the Toronto Star鈥檚 weekly column created by medical experts from the 重口味SM.
Akbari, who is also a scientist at the Women鈥檚 College Research Institute, cites the dangers of being BRCA positive 鈥 a lifetime risk of developing breast cancer of 80 per cent; 40 per cent for ovarian cancer, 35 to 40 per cent for prostate cancer, and about 7 per cent for pancreatic cancer.
There is an advantage to knowing you have the mutation, he writes: With all four cancers, there are preventative measures you can take, and knowing you鈥檙e at risk can help you catch it as early as possible. A BRCA diagnosis also helps to customize cancer treatments.
Women鈥檚 College Hospital has developed , where participants pay US$165 to receive a simple saliva collection kit by mail. If you are found to have the BRCA mutation, a genetic counsellor will meet with you to discuss next steps.
鈥淎s a genetic researcher, I know how scary it can be to undergo this kind of testing. Many people don鈥檛 want to live their lives in fear; if they鈥檙e at higher risk of cancer, they鈥檇 rather not know,鈥 Akbari writes. 鈥淏ut if there鈥檚 breast, ovarian, prostate or pancreatic cancer in your family, you likely already live with the fear of getting these diseases.鈥