重口味SM

Researchers use AI to optimize nutrient consistency in donated breast milk

'The new program ... helps to ensure that each batch of human donor milk meets the protein and calorie needs of preterm infants'聽
Breast milk being fed into an analyzer

A new data-driven framework developed by researchers at U of T and its hospital partners bypasses the need for a device to analyze donated breast milk (photo by Rogers Hixon Ontario Human Milk Bank)

A team of 重口味SM researchers is leveraging machine learning to optimize the macronutrient content of pooled human donor milk recipes.  

The researchers 鈥 led by Timothy Chan, a professor in the department of mechanical and industrial engineering in the Faculty of Applied Science & Engineering 鈥 introduce their data-driven optimization model . 

Chan and his team worked with Mount Sinai Hospital鈥檚  鈥 which provides donor milk to preterm and sick babies who are hospitalized across Ontario 鈥 as well as Deborah O鈥機onnor, a professor in the department of nutritional sciences in the Temerty Faculty of Medicine. 

鈥淔or a variety of reasons, many hospitalized infants do not have a full supply of mother鈥檚 milk. In this instance, human donor milk can be lifesaving particularly as it helps to protect preterm infants from necrotizing enterocolitis, a life-threatening bowel disease,鈥 says Sharon Unger, a neonatologist and the medical director of the Rogers Hixon Ontario Human Milk Bank who is also a professor in Temerty Medicine鈥檚 department of nutritional sciences.  

鈥淭he new program developed by Dr. Chan helps to ensure that each batch of human donor milk meets the protein and calorie needs of preterm infants.鈥  

Currently, many milk banks, including Mount Sinai鈥檚, rely on individual decision-making when pooling donor milk. This presents a significant challenge in producing a consistent donor milk product that contains sufficient macronutrients for premature and sick babies in neonatal intensive care units.  

鈥淚t takes a lot of time to create these recipes without a defined method,鈥 says Chan, who is also U of T鈥檚 associate vice-president and vice-provost, strategic initiatives.  

鈥淲hile there are studies that show that milk that comes from donors who are early in their postpartum period tends to be more protein-rich, our approach provides a good prediction of the actual macronutrient content that will allow milk bank employees to make better pooling decisions.鈥  

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Four beakers hold pooled donor milk at Mount Sinai Hospital鈥檚 Rogers Hixon Ontario Human Milk Bank (photo by Rogers Hixon Ontario Human Milk Bank)

Given that milk banks are often non-profit entities operating on lean budgets, a low-cost alternative to obtaining a consistent, nutrient-balanced product could be useful across the entire sector.   

While devices known as human milk analyzers can be used to measure the exact macronutrient content of鈥痚ach milk sample at a milk bank, they are costly and require extensive regulatory approval 鈥 and are therefore only used by half of all milk banks in North America. On top of that, analyzing every donation is a costly endeavour that is labour- and resource-intensive.  

鈥淥ur data-driven framework bypasses the need for a device to analyze the donor milk by using an artificial intelligence model to predict the macronutrient content of each donation,鈥 says Rachel Wong, who earned her master鈥檚 degree from U of T Engineering last year and is a lead researcher of the study.   

鈥淚n addition, by using an optimization model to choose which donations to pool together, we can increase the consistency of macronutrient content in the donor milk product.鈥濃  

The multi-phase study included a one-year implementation trial at the Rogers Hixon milk bank that was designed to test whether AI-informed models could help to fill the gap.   

In the first phase, researchers collected the necessary data to create a machine learning model to predict the macronutrient content of the pooled recipes, and then designed an optimization model to create the recipes based on macronutrient requirements 鈥 that is, the necessary levels of protein and fat.  

The team then created a simulation model to test the method before embarking on an experiment in the milk bank, which took place over 16 months in 2021 and 2022.  

鈥淪ince our study was performed in the milk bank during regular operating hours, rather than in a controlled environment, there were a number of unexpected challenges that we had to adapt to,鈥 Wong says.  

鈥淒uring the COVID-19 pandemic, the volume of donations fluctuated based on the provincial restrictions 鈥撯痙uring the lockdown periods there was an unprecedented increase in the number and volume of donations.  

鈥淲e also needed to adapt the AI decisions that had already been proposed to ensure that we abided with the milk bank鈥檚 operating protocols.鈥濃  

The last phase of the study began by observing the milk bank鈥檚 operation for six months and measuring the fat, protein and bacteria levels in the pooled recipes.   

For the following six months, the milk bank used the data-driven optimization framework to create the pooled milk recipes. At the end of the year, the researchers compared the optimized recipes to the previous ones to assess which recipes met the macronutrient targets.   

鈥淲e found that our pooled recipes met the bar for protein and fat simultaneously up to 75 per cent more often, without compromising other factors like an increase in bacteria,鈥 says Chan. 鈥淎nd it took us 60 per cent less time to make the recipes.鈥  

The team鈥檚 optimized recipes also have an added benefit for preterm and sick babies, who have underdeveloped digestive systems that make it especially crucial to ensure that the milk they are consuming isn鈥檛 overly rich in protein or fat.  

Chan鈥檚 team is currently working towards expanding the research to measure other nutrients in human donor milk to see if their models can optimize them. The research has won  from the Institute for Operations Research and the Management Sciences (INFORMS) and an Excellence in Quality and Safety award from Sinai Health.  

鈥淥ur ultimate goal is to show that our tool is applicable to other milk banks,鈥 says Chan. 鈥淲e would like to design a system that can plug into hospital systems to optimize recipes in a way that is sustainable for milk bank staff.鈥  

Wong says that the entire team is grateful to all those who have made the project possible.  

鈥淲e couldn鈥檛 have done this without all of the鈥痬others who donate to the milk bank and the staff who work incredibly hard to provide donor milk to infants across Ontario and beyond,鈥 she says.   

鈥淚 hope that this research will provide a framework to help milk banks across North America increase the consistency of macronutrient content in their donor milk product. The eventual end goal would be to see a downstream impact of improved growth and developmental outcomes for the infants that receive this donor milk.鈥濃

Engineering